ROLE OF HOMEOPATHY IN TACKLING RAISED IgE

Allergic responses typically affect the skin, gut, and respiratory tract, the major sites of parasitic invasion, it is thought that IgE evolved as a defence against parasitic infestation. Helminths stimulate a vigorous IgE production, they said have to the gate keeper function because they help to recognize he foreign material so early. Allergy triggered by IgE may be considered a beneficial function to the host; the typical allergic reactions of mucus secretion, itching, coughing, vomiting and diarrhea sneezing,bronchoconstriction, inflammation, , tear production are all mechanisms that expel allergenic proteins from the body. The immune response in allergy begins with sensitization. When, pollen allergens house dust mite are inhaled, the Langerhans cells in the epithelium lining the airways of the lungs and nose, internalize, process and then express these allergens on their cell surface.. In the allergic response, the plasma cell produces IgE antibodies, Once formed and released into the circulation, IgE binds to high affinity receptors on mast cells, leaving its allergen specific receptor site available for future interaction with allergen. Other cells known to express high-affinity receptors for IgE include basophils, Langerhans cells and activated monocytes. Production of allergen specific IgE antibodies completes the immune response known as sensitization.

When re-exposed, the allergen to IgE stimulates the immune system to initiate a more aggressive and rapid memory response.The immune system's response to allergen exposure can be divided into two phases. The first is immediate hypersensitivity or the early phasereaction that occurs within 15 minutes of exposure to the allergen. The second, or late phase reaction, occurs 4-6 hours after the disappearance ofthe first phase symptoms and can last for days or even weeks. During the early phase reaction chemical mediators released by mast cells including

histamine, prostaglandins, leukotrienes and thromboxane produce local tissue responses characteristic of an allergic reaction. In the respiratory tractbronchoconstriction in the lung, leading to wheezing. During the late phase reaction in the lung, cellular infiltration, fibrin deposition and tissuedestruction resulting from the sustained allergic response lead to increased bronchial reactivity, edema and further inflammatory cell recruitment.

Significance of IgE in Allergic rhinitis

Allergic rhinitis (AR) is a common chronic disease which has significant impact on quality of life, loss of productivity, and financial expenditure Diagnosis of AR is performed by clinical parameters as well as measurement of specific IgE reactivity through in vitro or in vivo methods. There is currently no accepted screening test for differentiating AR from diseases with similar symptoms. The measurement of total serum IgE level is a low-cost test that is used in diagnosis of AR.

Elevated total IgE has a high positive predictive value for identification of in vitro specific IgE in the diagnosis of allergic rhinitis

How can it be prevented?

Avoidance of allergen exposure has only partially been successful in prevention of IgE-sensitization. Avoidance is difficult to implement and can severely restrict lifestyle, benefits are small, and long-term effects are doubtful. Until

recently it has been recommended that infants at high allergy risk may benefit through avoidance of pets and dust mites during the first year of life,but new research suggests that in some individuals, such exposures may result in immunological diseases. Prevention of IgE sensitization is possible in the occupational environment by theelimination of sensitizing agents from the workplace or implementing measures to prevent employee exposure. Smoking has been shown to be a riskfactor for the development of IgE antibodies against occupational gents and has an adjuvant effect with irritant gases, such as ozone and sulphur.So apart from other benefits to health, non-smoking policies in the workplace may have a role to play in preventing IgE sensitization.

Homeopathic  approach

As in other cases ultimate cure occur only after administration of a constitutional remedy.

ARS LB, AMM. CARB, ALLIUM CEPA, NUX VOM CUPRUM MET  are the main remedies to tackle acute episode .

But to eradicate the tendency better to think about THUJA/TUBERCULINUM/ PSORINUM/SULPHUR/ OR CARCINOSINUM

And of these tuberculinum/ psorinum/suphur ranks high

An example-

Case of an 70 year old man with frequent sneezing and cough.

Found the acute remedy as nuxvom, and tried in 30 potency for  a week as tds. After getting symptomatic improvement psorinum 1M/2D  was tried

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